MicroRNAs Are Necessary for Vascular Smooth Muscle Growth, Differentiation, and Function
نویسندگان
چکیده
منابع مشابه
Integrative Physiology/Experimental Medicine MicroRNAs Are Necessary for Vascular Smooth Muscle Growth, Differentiation, and Function
Objective—Regulation of vascular smooth muscle (VSM) proliferation and contractile differentiation is an important factor in vascular development and subsequent cardiovascular diseases. Recently, microRNAs (miRNAs) have been shown to regulate fundamental cellular processes in a number of cell types, but the integrated role of miRNAs in VSM in blood vessels is unknown. Here, we investigated the ...
متن کاملMicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function.
OBJECTIVE Regulation of vascular smooth muscle (VSM) proliferation and contractile differentiation is an important factor in vascular development and subsequent cardiovascular diseases. Recently, microRNAs (miRNAs) have been shown to regulate fundamental cellular processes in a number of cell types, but the integrated role of miRNAs in VSM in blood vessels is unknown. Here, we investigated the ...
متن کاملMicroRNAs in angiogenesis and vascular smooth muscle cell function.
The Human Genome Project was barely completed in 2003 before a new quest was launched: this time, in a search for short stretches of RNA called microRNA. The belief that these miniature molecules, which had only been discovered a decade earlier, were major regulators of genetic function gained momentum in the intervening years and sparked a worldwide interest in the physiologic and pathologic r...
متن کاملInflammation and Vascular Calcification Causing Effects of Oxidized HDL are Attenuated by Adiponectin in Human Vascular Smooth Muscle Cells
The role of oxidized high-density lipoprotein (oxHDL) and the protective effects of adiponectin in terms of vascular calcification is not well established. This study was conducted to investigate the effects of oxHDL with regards to inflammation and vascular calcification and to determine the protective role of adiponectin in attenuating the detrimental effects of oxHDL. Cell viability, mineral...
متن کاملThe Role of MicroRNAs in Vascular Diseases; Smooth Muscle Cell Differentiation and De-Differentiation
Vascular smooth muscle cells (VSMCs) undergo two important physiological processes such as differentiation (contractile state) and dedifferentiation (proliferative state) during vascular diseases. In general, a prerequisite for pathological and physiological vascular remodeling processes such as atherosclerosis, hypertension, and restenosis after angioplasty is the phenotype alteration of VSMCs...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2010
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.109.200873